Synthesis of silk-inspired polyurethanes with a rigid segment containing GlyAlaGlyAla tetrapeptide links

摘要：

As the featured peptide sequence of silkworm silk protein, GlyAlaGlyAla (GAGA) tetrapeptide was synthesized by traditional liquid-phase peptide synthesis method with Boc-protected glycine and alanine as starting materials, and was transformed to its derivative with two end-amido groups. The derivative was incorporated into the backbone of the classical synthetic copolyurethane as a chain extender. This synthesis strategy allows the fabrication of a new class of thermoplastic polyurethane elastomer to mimic the structure and properties of silk fibers of silkworms and even spiders, which combines traditional synthetic polymer chains with peptide sequences.

作者: LIU Hongtao XU Weilin ZOU Hantao HUANG Jingjing LIU Xin

作者单位: College of Textiles, Donghua University, Shanghai 201620, P.R.China Key Laboratory for Green Proce Key Laboratory for Green Processing & Textiles of New Textile Materials (Textile Research Center, College of Textiles, Donghua University, Shanghai 201620, P.R.China

会议类型: 国际会议

会议名称: 2009 International Conference on Advanced Fibers and Polymer Materials(2009年先进纤维与聚合物材料国际学术会议)

会议地点: 上海

会议语种:英文

页码: 697-699

在线出版日期: 2009-10-21（万方平台首次上网日期，不代表论文的发表时间）