Preparation of shikonin-loaded polyacrylonitrile nanofibers using electrospinning
Polyacrylonitrile (PAN; Mw~80000) nanoscale fibers containing shikonin from the plant Lithospermum erythrorhizon were successfully prepared. In herbal medicine shikonin is widely known for its anti-tumor, antioxidant, and anti-inflammatory properties Here we describe for the first time a electrospun system involving PAN (8% and 11%, w/v in N, N-dimethylacetamide) containing 5 wt% shikonin (based on the weight of PAN powder). Incorporation of the drug into the PAN media did not appear to influence the morphology of the resulting fibers, as the surface of the shikonin-loaded PAN fibers were uniform and smooth. In addition, high drug loading efficiency (>91%) was successfully achieved. In vitro drug release studies demonstrated an initial rapid release followed by a slower constant. These findings demonstrate the controlled release of drugs from PAN fibers could provide new protocols for clinical use.
HAN Jie BRANFORD-WHITE Christopher ZHU Limin
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620 Institute for Health Research and Policy, London Metropolitan University, London, N7 8DB, UK
国际会议
2009 International Conference on Advanced Fibers and Polymer Materials(2009年先进纤维与聚合物材料国际学术会议)
上海
英文
827-830
2009-10-21（万方平台首次上网日期，不代表论文的发表时间）