Biomimetic calcium phosphate mineralized electrospun PLLA nanofibers by electrochemical deposition for bone tissue engineering
This study aims to develop a facile and fast fabrication method for preparation mineralized calcium phosphate coating on the surface of electrospun PLLA nanofibers by combining electrospinning and electrochemical deposition technique. In this approach, poly-L-lactide (PLLA) nanofibers were firstly prepared by electrospinning and deposited on the surface of the platinum electrodes, followed by electrochemical deposition of fibers-covered electrodes to achieve uniform and stable calcium phosphate. The resulting deposits were then characterized by X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The results indicated that the deposits consisted of a mixture of DCPD and HA when deposition was performed for 60 min. This hybrid fibrous scaffold has the voltage to mimic the components and structure of nature bone extracellular matrix and provide a more cell-friendly interface for bone regeneration.
HE Chuanglong QIU Lijun XU Xiaohong WANG Hongsheng MO Xiumei
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua Universit College of chemistry and chemical engineering and biological engineering,Donghua University, Shang
国际会议
2009 International Conference on Advanced Fibers and Polymer Materials(2009年先进纤维与聚合物材料国际学术会议)
上海
英文
1032-1035
2009-10-21（万方平台首次上网日期，不代表论文的发表时间）