Drug release from films and electrospun fiber sheets of poly(3-hydroxybutyrate- co-3-hydroxyvalerate)

摘要：

Films and electrospun fiber sheets made from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) are explored as drug delivery vehicles using tetracycline hydrochloride as a model drug. In order to assist in choosing suitable process conditions for spinning, the viscosities of PHBV solutions in chloroform were investigated. The fiber sheets were electrospun and the films were casted from chloroform solutions containing a small amount of methanol to solubilize the drug. The vitro release of the tetracycline hydrochloride from these new drug delivery systems in phosphate buffer solution (PBS) was followed by UV-VIS spectroscopy. The morphology of these new drug loaded materials before and after release was investigated by SEM.

作者: WANG Wei Lan Ping CAO Jianda ZHANG Yu CHEN Yanmo

作者单位: Department of Textile Engineering, Jiaxing College, Zhejiang, 314001, P.R.China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua Universit

会议类型: 国际会议

会议名称: 2009 International Conference on Advanced Fibers and Polymer Materials(2009年先进纤维与聚合物材料国际学术会议)

会议地点: 上海

会议语种:英文

页码: 1040-1043

在线出版日期: 2009-10-21（万方平台首次上网日期，不代表论文的发表时间）