The preparation of ion-exchange nanofiber membranes and their application for drug delivery
The objective of this study was to prepare ion-exchange nanofiber membranes from electrospun polyacrylonitrile (PAN) non-woven mats through alkaline hydrolysis, to investigate the binding efficiency of the drug onto the nanofibers and the in vitro drug release profiles. Sodium salicylate was selected as the model drug. Scanning electronic microscopy images showed that the nanofibers had a smooth surface and a uniform structure both before and after the hydrolysis treatment. FT-IR results suggested that the main interaction between fibers and model drugs was electrovalent bonding. The in vitro dissolution tests indicated that the drug release profiles were improved by the ion-exchange nanofibers with a long release time period and a weakened initial burst release effects. All the results demonstrated that the alkaline hydrolysis of PAN nanofibers was useful for the possible applications of ion-exchange membranes as transdermal drug delivery systems or topical drug delivery systems.
ZHANG Xiaofei YU Dengguang BRANFORD-WHITE Chris ZHU Limin
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620 Institute for Health Research and Policy, London Metropolitan University, London, N7 8DB, UK
国际会议
2009 International Conference on Advanced Fibers and Polymer Materials(2009年先进纤维与聚合物材料国际学术会议)
上海
英文
1052-1054
2009-10-21（万方平台首次上网日期，不代表论文的发表时间）