The research on cytotoxicity and cellular uptake of mPEG-PLGA-PLL nanoparticles

摘要：

The aim of this study was to investigate the cytotoxicity and cellular uptake of mPEG-PLGA-PLL nanoparticles. The mPEG-PLGA-PLL nanoparticles were prepared by “oil-in-water solvent evaporation method. The cytotoxicity and cellular uptake of mPEG-PLGA-PLL nanoparticles were evaluated by MTT assay and Confocal Laser Scanning Microscopy (CLSM). We found that mPEG-PLGA-PLL nanoparticles showed neglectable cytotoxicity, and the uptaken nanoparticles were mainly localized in cytoplasm.

作者: LIU Peifeng ZHU Mingjie LI Yaogang WANG Hongzhi DUAN Yourong

作者单位: College of Materials Science & Engineering, Donghua University, Shanghai 201620, P.R.China Cancer I Cancer Institute of Shanghai Jiao Tong University, Shanghai 200032, P.R.China College of Materials Science & Engineering, Donghua University, Shanghai 201620, P.R.China

会议类型: 国际会议

会议名称: 2009 International Conference on Advanced Fibers and Polymer Materials(2009年先进纤维与聚合物材料国际学术会议)

会议地点: 上海

会议语种:英文

页码: 1190-1192

在线出版日期: 2009-10-21（万方平台首次上网日期，不代表论文的发表时间）