Preparation and characterization of silk fibroin blended hydroxybutyl chitosan nanofibrous scaffolds
The native extracellular matrix (ECM) is composed of a cross-linked porous network of multifibril collagens and glycosaminoglycans. Nanofibrous scaffolds of silk fibroin (SF) and hydroxybutyl chitosan (HBC) blends were fabricated using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) and trifluoroacetic acid (TFA) as solvents to biomimic the native ECM via electrospinning. SEM showed the average nanofibrous diameter increased with increasing the blend ratio of SF to HBC. The results of X-ray diffraction and crystallinities cleared SF/HBC blend nanofibers formed new crystal structure. However, FTIR showed HBC did not induce conformation of SF transforming from random coil form to β-sheet structure. The results indicated rearrangement of molecular chain HBC and SF to form a new crystal structure due to strong hydrogen bonding between HBC and SF.
ZHANG Kuihua WANG Hongsheng FAN Linpeng MO Xiumei
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materi Biomaterials and Tissue Engineering Lab, College of Chemistry and Chemical Engineering and Biolog State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materi
国际会议
2009 International Conference on Advanced Fibers and Polymer Materials(2009年先进纤维与聚合物材料国际学术会议)
上海
英文
1219-1221
2009-10-21（万方平台首次上网日期，不代表论文的发表时间）