Changes in the repair of mitochondrial DNA during ageing due to exercise and caloric restriction

摘要：

Introduction The mitochondrial theory of aging suggests ageing results from declining mitochondrial function, due to damage and mutation in mitochondrial DNA (mtDNA). Mitochondrial generation of reactive oxygen species (ROS) is increased in rats with ageing. mtDNA are targets for ROS-induced damage and accumulate hydroxylated bases, such as 8-hydroxy-2deoxyguanosine (8-oxoG). Oxidative damage to mtDNA is repaired by the base excision repair (BER) pathway.

作者: Zeng Zhengzhong Wen Li Wu Zhiyi

作者单位: Tianjin University of Sports, China

会议类型: 国际会议

会议名称: 2008年奥林匹克科学大会

会议地点: 广州

会议语种:英文

页码: 772-773

在线出版日期: 2008-08-01（万方平台首次上网日期，不代表论文的发表时间）