Preparation and Structure Characterization of β-Caryophyllene Alcohol from Mason Pine Pitch and Its Antitussive and Expectorant Effects

摘要：

Without separation of Heavy Turpentine from Mason Pine Pitch, β-Caryophyllene Alcohol can be prepared directly with β-caryophyllene in purity 99.76％ and yield 6.6％, i.e., 43％ with regard to β-Caryophyllene. Its structure was confirmed by FT-IR, 1H NMR, 13C NMR, 13C NMR-DEPT, 1H-1H COSY, C-H COSY, LONG-RANGE C-H COSY, MS and EA. Animal experiments indicate that the title compound has significant antitussive, expectorant effect with clear dose -effect relationship. Effective administration of cough relieving in rats and sputum removing in rats and doves was 39.6 mg/kg, 12.4 mg/kg, 45.4 mg/kg respectively, so it can be applied to Antitussive, Expectorant.

关键词： Mason Pine Pitch β-Caryophyllene Alcohol structure characterization Antitussive effects Expectorant effects

作者: Hong-Jun LIU Xiao-Hui YANG Fei JING Yong-Hong ZHOU

作者单位: Institute of Chemical Industry of Forest Products, CAF Key and Open Lab. on Forest Chemical Engineer Institute of Chemical Industry of Forest Products, CAF Key and Open Lab. On Forest Chemical Engineer

会议类型: 国际会议

会议名称: International Conference on Chemical and Biological Utilization of Biomass Resources 2010(2010年生物质资源化学利用国际学术研讨会)

会议地点: 南京

会议语种:英文

页码: 342-351

在线出版日期: 2010-10-22（万方平台首次上网日期，不代表论文的发表时间）