Synthesis and Bacteriostatic Activity of Nitrogen-containing Derivatives of 2-hydroxy-3-pinanone
A new series of N-alkyl-2-hydroxy-3-pinanamines were synthesized from α-pinene. 2-hydroxy-3-pinanone was obtained from α-pinene by oxidation with potassium permanganate, and then it was reacted with n-propylamine, n-butylamine, isobutylamine, n-hexylamine, cyclohexylamine, phenylamine, benzylamine, respectively under catalysis of boron trifluoride-diethyl etherate to afford Schiff bases, which were further reduced with NaBH4 to get N-alkyl-2-hydroxy-3-pinanamines. The structures of N-alkyl-2-hydroxy-3-pinanimines and N-alkyl-2-hydroxy-3-pinanamines were determined by FT-IR, GC-MS, 1H NMR, and 13C NMR techniques. Antifungal biological activities about all synthesized compounds were tested. Antifungal experiment indicated that N-n-hexyl-2-hydroxy-3-pinanimine, N-cyclohexyl-2-hydroxy-3-pinanimine and N-n-cyclohexyl-2-hydroxy-3-pinanamine had strong antifungal effects to E.coli and S.aureus.
Wang-wei AO Zhong-bao BI Hao-jin LI Shi-fa Wang
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037
国际会议
南京
英文
622-632
2010-10-22（万方平台首次上网日期，不代表论文的发表时间）