THE DIFFUSION COEFFICIENT OF MAGNETIC FLUID IN TUMOR TISSUE—THEORETICAL METHOD
The magnetic fluid has been an important drug for treating tumor disease during the method of Hyperthermia therapy. Among the recent studies on the transportation of drugs, most of the researchers were pointing on isotropism and not entirely considering the geometrical factors. During our research, the free diffusion coefficient and effective diffusion coefficient of magnetic fluid diffuses in tumor tissue are deduced using Fick’s First Law by considering the tumor tissue as porous media and assuming the shapes of tumor to be circle or ellipse or a combination of them. In the porous media model, we regarded the capillary & cell as the substrate of porous media and tumor interstitial as the pore. The magnetic fluid is a kind of fluid with magnetism which can produce heat to treat tumor while applying the alternating magnetic field. The deduced expression of effective diffusion coefficient is a function of geometrical factors with no empirical constants and presents good agreements with the existing value especially when the ratio of distance (between the substrates of tumor) to the size of tumor tissue reaches to a considerable value (bigger than 5), with relative error less than 5％. We considered the tumor tissue to be anisotropism, and this work may be meaningful for the study of drug delivery of tumor tissue.
Peng Xu Kai Yue Xinxin Zhang
Thermal Engineering Department, University of Science and Technology Beijing, Beijing, China, 100083
国际会议
The Ninth Asian Thermophysical Properties Conference(第九届亚洲热物理性能会议 ATPC 2010)
北京
英文
1205-1209
2010-10-19（万方平台首次上网日期，不代表论文的发表时间）