Developmental toxicity of triadimefon in embryo-larval stages of zebrafish

摘要：

Triadimefon, a triazole fungicide, has been widely detected in the environment, but few studies have assessed its effect on aquatic organisms. The present study evaluated the effect of triadimefon in embryolarval stages of zebrafish. Zebrafish embryos exhibited teratogenic effects of bent spine, uninflated swim bladder and other malformations after exposure to various triadimefon concentrations (0-4.0 μg/mL) from 6 to 120 h post-fertilization (hpf). We observed the locomotor activity namely spontaneous movement in embryos and swimming activity in larvae to assess the neurotoxicity. This is the first study to detection the neurotoxicity and teratogenic of triadimefon in zebrafish. We also inferred the spontaneous movement was related to the hatching rate and the potential course of the uninflated swim bladder. The results further the understanding of the toxicity of triadimefon to aquatic organisms and suggest the need for additional research to identify the mode of triadimefon toxicity.

关键词： neurotoxictity teratogenic effects zebrafish triadimefon

作者: Shaoying Liu Juhua Chang Guonian Zhu

作者单位: Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hang Zhou, 310012, China

会议类型: 国际会议

会议名称: 2010 International Conference on Digital Manufacturing and Automation(2010 数字制造与自动化国际会议 ICDMA 2010)

会议地点: 长沙

会议语种:英文

页码: 552-555

在线出版日期: 2010-12-18（万方平台首次上网日期，不代表论文的发表时间）