Exploration of in vivo Effect Assessment Factor Monitoring by Near-infrared Spectroscopy during LITT
By studying the variation trends of the absorption coefficient (μa) and the reduced scattering coefficient (μa), which were monitored in vivo by functional near infrared spectroscopy (fNIRS) system in real time during laser induced interstitial thermotherapy (LITT), the optimized near infrared effect assessment factor would be explored. In vivo measurements of the absorption coefficient (μa) and the reduced scattering coefficient (μa) were performed with a functional near infrared spectroscopy system during LITT. Fresh porcine liver tissue samples in vitro and the subcutaneous implanted rat liver cancers were examined in different laser doses and define heating times. The absorption coefficient obtained by the fNIRS increased in the pork liver experiments, but decreased in the rat liver cancer experiments. The reduced scattering coefficient increased in the pork liver experiments and the rat liver cancer experiments, it increased quickly at beginning, and gradually reached the stable state. Therefore, the reduced scattering coefficient is more suitable for reflecting the progress of damage during different biological tissues LITT than the absorption coefficient. This conclusion will effectively guide the study of suitable therapy effect assessment system during LITT in real time.
Ai-ping Qian Guo-ran Hua Hua Zhang Zhi-yu Qian
School of Mechanical Engineering, Nantong University, Nantong, Jiangsu 226019,China Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, J
国际会议
3rd International Photonics & OptoElectronics Meetings(第三届国际光子与光电子学会议 POEM 2010)
武汉
英文
1-6
2010-11-03（万方平台首次上网日期，不代表论文的发表时间）