NIR area array CCD-based singlet oxygen luminescence imaging for photodynamic therapy

摘要：

In this work, a near-infrared CCD-based singlet oxygen luminescence two-dimensional imaging method is proposed to detect singlet oxygen by its 1270nm luminescence. Two-dimensional singlet oxygen images with its near-infrared luminescence during photosensitization could be obtained with a CCD integration time of Is, without scanning. The data presented shows a linear relationship between the singlet oxygen luminescence intensity and sample concentration. This method provides a detection sensitivity of 0.00189mg/ml (Hematoporphyrin monomethyl Ether dissolved in ethanol) and a spatial resolution better than lOCum. We applied this method in vivo to demonstrate its potential in monitoring photodynamic therapy.

作者: Bolin Hu Yonghong He Zhiyi Liu

作者单位: Laboratory of Optical Imaging and Sensing, Graduate School at Shenzhen,Tsinghua niversity. Shenzhen, Laboratory of Optical Imaging and Sensing, Graduate School at Shenzhen,Tsinghua University. Shenzhen

会议类型: 国际会议

会议名称: The 9th International Conference on Photonics and Imaging in Biology and Medicine(第九届生物医学光子学与成像技术国际学术研讨会 PIBM 2010)

会议地点: 武汉

会议语种:英文

页码: 1-9

在线出版日期: 2010-11-02（万方平台首次上网日期，不代表论文的发表时间）