Ecotoxicological Risk of Residual Solvents in Pharmaceuticals on Daphnia Magna
Ecotoxicity of residual solvents of Pharmaceuticals on dapbnia magna was studied by acute test. The results showed the order of toxicity of residual solvents of terramycin, thiamine bydrochloride and thiamine mononitrate was benzene > carbon tetrachloride > 1, 2-dichloroethane > 1, 1dichloroethylene > 1, 1, 1-trichloroethane, dichloromethane > tetrahydrofuran > toluene > methanol> ethyl acetate = acetic acid = ethanol, Nmethylpyrrolidon > N, N-dimethylacetamide > methanol > aether, respectively. The ecotoxicity of methanol in combined system was more severe than that of in single system. The LC5Os of methanol were 72.21, 91.94 and 3-357 X104 mg/L in thiamine hydrochloride, thiamine mononitrate and in single system, respectively. It was likely that the toxic effect of residual solvents increased in the presence of potential competitors. The study provided baseline information which was necessary to assess the potential hazard of some residual solvents released into water ecosystems.
Residual Solvent Ecotoxicity Pharmaceuticals
Minling Gao Wenhua Song Chunxiao Sun Jinhua Zhang Wei Sun
Tianjin Polytechnic University Tianjin, China
国际会议
昆明
英文
229-231
2010-10-17（万方平台首次上网日期，不代表论文的发表时间）