Biocompatibility of HAP/Ti Gradient Coating by Microarc Oxidation and Biomimetic Process
This study is to evaluate the biocompatibility of HAP/Ti gradient coating by microarc oxidation and biomimetic process. Titanium alloys were activated by microarc oxidation (MAO),and immersed in simulated body fluid to prepare HAP/Ti gradient coating. Scanning electron microscopy (SEM) had been used to investigate the microstructure of the coatings. The biocompatibility of the coatmgs was evaluated by animal acute and subacute toxicity test,micronucleus test,hemolysis test, and oral mucosa test. The results showed HAP/Ti gradient coating was successfully fabricated on the substrate. The animal experiment showed the coating had not short-term toxicity,oral mucosa irritation,and micronucleus occurrence rate was 3.2％and hemolysis rate was 2.5％. The HAP/Ti gradient coating made by MAO and biomimetic process showed good bio-security and compatibility, it may be new oral implant materials.
Titanium alloys micro-arc oxidation HAP biocompatibility
Zhang Dong Zhang Bao-Ping Li Zhi-Ge Wang Lin Liu Bin Wang Jin-Qing
School of Stomatology,Lanzhou University,Lanzhou 730000 China State Key Laboratory of Solid Lubrication,Lanzhou Institute of Chemical Physics,Chinese Academy of S
国际会议
Frist Annual Meeting on Testing and Evaluation of Inorganic Materials(第一届全国无机材料测试与评价学术年会)
南昌
英文
325-328
2010-04-28（万方平台首次上网日期，不代表论文的发表时间）