A New Type of Colored Alumina/glass Composite Biological Safety Assessment - Oral Mucous Membrane Irritation and Skin Sensitivity Tests
Objective: to describe and demonstrate an oral mucosa irritation and a skin sensitivity test for evaluation of the biological safety of a colored alumina/glass composite (AGC). Methods: colored alumina/glass composite and control materials were sutured to mucine bilateral cheek pouch mucosa,in a position for gross observation and for histological and cytological examination; skin irritation activity of the composite was tested by intradermal injection of a guinea pig test solution,by inducing,enhancing, and stimulating the allergic response observed afier local tissue exposure. Results: colored AGC in mouse cheek pouch mucosa stimulated the same reaction as the control,with no significant inflammatory reaction or infiltration of inflammatory cells. Guinea pigs showed no obvious erythema or edema from the irritation test,such that the assessment of colored AGC skin allergy response in mice was 0％. Conclusion: colored AGC was benign towards mouse oral mucosa and elicited no allergic skin inflammation response,indicating that in these aspects this material had good biological safety.
Alumina/glass composite Mucous membrane irritation test Skin sensitivity test
Huai-Xiu Lu Bin Deng Long-quan Shao Yuan-Fu Yi Jie Liu Wei-Wei Zhang Ning Wen
Department of Stomatology,Navy General Hospital,Beijing 100048,China Department of Stomatology,Chinese PLA General Hospital,Beijing 100853,China Department of Stomatology,Nanfang Hospital of Southern Medical University,Guangzhou 510515,China Department of Stomatology,General Hospital of Armed Police Forces,Beijing 100039,China
国际会议
Frist Annual Meeting on Testing and Evaluation of Inorganic Materials(第一届全国无机材料测试与评价学术年会)
南昌
英文
462-465
2010-04-28（万方平台首次上网日期，不代表论文的发表时间）