SYNTHESIS OF REGIOSELECTIVE FUNCTIONALIZED CELLULOSIC MATERIALS
The synthesis of value-added materials from naturally abundant polymers such as cellulose is of significant importance. In the present research, cellulose was reacted with dimethylthexylsilyl chloride to form regioselective 2,6-di-O-thexyldimethylsilyl cellulose (2,6-TDMS cellulose). With one end of poly(ethylene glycol) (PEG) being protected with an allyl group, the other end of PEG was functionalized and then attached to the C3 position of the regioselective 2,6-TDMS cellulose. A relatively high degree of substitution of 0.45~0.47 was confirmed by 1H NMR. The allyloxy group at the free end of PEG was then completely oxidized into a hydroxypropoxy group, followed by conversion to a chloropropoxy group, and further to an azidopropoxy group. The end azido group can potentially be used for linking bioactive molecules by further reduction into an amine group or via click chemistry to react with bioactive molecules containing an alkynyl group.
cellulose regioselective poly(ethylene glycol) 3-O-poly(ethylene glycol)-2,6-di-O-thexyldimethylsilyl cellulose Azide
William Z. Xu John F. Kadla
Advanced Biomaterials Chemistry Laboratory, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
国际会议
16th International Symposium on Wood,Fiber and Pulping Chemistry(第十六届木材、纤维及制浆化学国际会议)
天津
英文
371-376
2011-06-08（万方平台首次上网日期，不代表论文的发表时间）