ONE-STEP PREPARATION AND LOADING OF BACTERIAL CELLULOSE AEROGELS WITH BIOACTIVE COMPOUNDS FOR SLOW-RELEASE APPLICATIONS

摘要：

The current paper communicates a straightforward approach to highly porous,ultra-lightweight bacterial cellulose aerogels with densities of down to 8 mg/cm3 using supercritical carbon dioxide as drying medium.Bacterial cellulose alcogels were confirmed to feature good dimensional stability throughout scCO2drying.The obtained aerogels are quantitatively rewettable without significant shrinking which renders them interesting matrices for controlled release applications.Antisolvent precipitation of bioactive compounds inside the alcogel pore network and subsequent conversion of the loaded lyogels into aerogels using scCO2 was shown to be an effective method as the two steps can be performed at once under only slightly different pressure conditions.The release profiles of the two model compounds Lascorbic acid and D-panthenol were predicted using the Korsmeyer model and compared with experimental values.The good agreement between predicted and measured values confirmed that the release of similar bioactive compounds can be largely controlled by the thickness of the bacterial cellulose layer.

关键词： aerogels bacterial cellulose supercritical drying controlled release

作者: Emmerich Haimer Christian B.Schimper Nikita Aigner Martin Wendland Antje Potthast Thomas Rosenau Falk Liebner

作者单位: Department of Materials Sciences and Process Engineering,University of Natural Resources and Life Sc Department of Chemistry,University of Natural Resources and Life Sciences,Muthgasse 18,Vienna.

会议类型: 国际会议

会议名称: 16th International Symposium on Wood,Fiber and Pulping Chemistry(第十六届木材、纤维及制浆化学国际会议)

会议地点: 天津

会议语种:英文

页码: 1297-1301

在线出版日期: 2011-06-08（万方平台首次上网日期，不代表论文的发表时间）