The stability of excess-electron attached Thymine-Glycine dimer
Low energy electron attachment is important reason for DNA damages including breaks in bases and strands. Some recent experiments show that at the presence of amino acids, DNA damages will be decreased. To trace the molecular mechanism behind the protection of amino acid to DNA, we study the interactions between glycine and thymine before and after an excess electron is vertically attached with density functional theory. Our results show that in all 6 planar dimers of canonical glycine and thymine, the 34-A is most favorable after the electron is attached. The electron is mostly localized on thymine with a proton transfering from glycine to thymine. It might be one possible single point mutation of DNA or RNA during the protein-binding phase in DNA replication process.
Amino acid DNA bases Excess-electron Dimer stability
Yugai Huang Xia Fang Bin Gu
College of Life Science and Chemistry, Jiangsu Institute of Education,Nanjing 210013, China College of Math and Physics, Nanjing University of Information Science and Technology,Nanjing 210044
国际会议
The 5th International Congress on Mathematical Biology(第五届国际生物数学大会 ICMB 2011)
南京
英文
1649-1654
2011-06-01（万方平台首次上网日期，不代表论文的发表时间）