MEMS-based micro chamber PCR chip thermal analysis and structural improvement

摘要：

The heat conduction characteristic of integrated micro chamber Poiymerase Chain Reaction (PCR) biochip based on Micro Electro Mechanical System (MEMS) technology is analyzed by COMSOL Multiphysics. Reaction solution vaporize in the middle air layer between he reaction solution and glass cover, and the temperature differences lead to a condensation of the gaseous reaction solution to the glass cover, and this reduce reaction efficiency and reaction output, also affect the following work of PCR and chip cleaning. The improved of the typical integration micro chamber PCR chip applies the same structure of serpentine heat resistance at the top and bottom of reaction chamber, and heat resistances are controlled by the same microprocessor. The simulation results show that improved structure restrain the condensation of the gaseous reaction solution, and provided a uniform temperature for the PCR reaction chamber.

关键词： MEMS PCR Thermal Analysis Biochip

作者: Deng Zhong-hang Ge Yue-tao Guan Wei-guo Cao Qi-ke

作者单位: School of Electronic Engineering Beijing University of Posts and Telecommunications Beijing,China

会议类型: 国际会议

会议名称: 2010 International Conference on Computer,Mechatronics,Control and Electronic Engineering(2010计算机、机电、控制与电子工程国际会议 CMCE 2010)

会议地点: 长春

会议语种:英文

页码: 130-133

在线出版日期: 2010-08-24（万方平台首次上网日期，不代表论文的发表时间）