Safety Evaluation of Gemini-Type Quaternary Ammonium Salt Antibacterial Reagent

摘要：

To assess safety of gemini-type quaternary ammonium salt as a germicide, toxicity characteristics of benzyl dimethyl dodecyl ammonium chloride BAC, 1-methyl-1-dodecyl piperazinium chloride MDP, 1,4-didodecyl piperazinium dichloride DDP and l,l-(decanedioyl)bis (4-methyl -4-dodecyl piperazinium chloride)s DCP were evaluated by the investigation of minimum inhibitory concentrationMIC, minimum hemolysis concentrationMC50, cytotoxicityLC50 and acute oral toxicity. The results revealed that MIC, HC50and LC50of DCP are 1.6, 15.5 and 31.0 μmol-L-1, respectively. That of DDP are 8.3, 8.0 and 25.0 μmol-L-1, respectively. That of DMP are 24.1, 31.0 and 87.0 μmol-L-1, respectively. That of BAC are 28.9, 38.4 and 120.0 μmol-L-1, respectively. All of QACs used in the acute oral toxicity test belongs to actually non-toxic grade. It is suggest that gemini-type quaternary ammonium salt antibacterial reagent has higher safety than mono-type, and HC50/MIC or LC50/MIC as a parameter is more important to safety evaluation of QACs antibacterial reagent.

关键词： Safety antimicrobial activity hemolytic activity cytotoxicity acute oral toxicity quaternary ammonium compounds

作者: ZHOU Fei SUN Yuhan WANG Qinqin ZHANG Zhili

作者单位: College of Environment & Chemical Engineering, Xian Polytechnic University, Xian 710048, Shaanxi, China

会议类型: 国际会议

会议名称: The 2010 International Symposium on Safety Science and Technology(2010 安全科学与技术国际会议)

会议地点: 杭州

会议语种:英文

页码: 177-181

在线出版日期: 2010-10-26（万方平台首次上网日期，不代表论文的发表时间）