A simple program to calculate normal tissue complication probability in external beam radiotherapy for nasopharyngeal carcinoma
Purpose: to provide a simple program to calculate the normal tissue complication probability (NTCP) based on the equivalent uniform dose (EUD) and to illustrate the implementation of the NTCP model as a research tool of intensity-modulated radiotherapy (IMRT) plans for nasopharyngeal carcinoma (NPC). Methods and materials: As a high-level technical computing language, Matlab was chosen to implement the EUD-based Lyman-Kutcher-Burman NTCP mathematical model. The normal tissue DVHs of three patients with NPC were obtained from Elekta precise treatment planning system. The necessary parameters for the model were clearly defined. Results: The computer code is presented and saved as a Matlab program. The ELD and NTCP values of four normal tissues were generated. Conclusion: The model has an excellent ability in fitting the normal structures tolerance values in this study. It is helpful for clinicians to select safer and more effective treatment plans.
normal tissue complication probability equivalent uniform dose dose-volume histogram nasopharyngeal carcinoma program
Li Bing Zhou Zhengdong Shen Junshu Dai Wei
Laboratory of Image Science and Technology Southeast University Nanjing, China Department of Radiation Oncology, Jinling Hospital Nanjing, China
国际会议
太原
英文
493-496
2010-10-22（万方平台首次上网日期，不代表论文的发表时间）