Identifying kinetic constants of ion channel of hierarchical type

摘要：

We have developed a totally different approach from Maximum likelihood widely employed to estimate the kinetic constants of single-ion channels of hierarchical mechanism. It is found that all kinetic constants are uniquely determined by the probability density functions of their lifetime and death-time of the middle states. An algorithm to calculate all kinetic constants is provided, which employs the intrinsic properties of the Markov process. Once we have them, all subsequent calculations are then automatic and exact.

关键词： Single-ion channel Markov chain on hierarchical type kinetic constants

作者: Xuyan Xiang Yingchun Deng Xiangqun Yang Jianbin Li

作者单位: College of Mathematics and Computing Science Hunan University of Arts and Science P.R.of China College of Mathematics and Computer Science Hunan Normal University Scientific Research Management Hunan Cotton Research Institute P.R.of China

会议类型: 国际会议

会议名称: The 2010 International Conference on Computer Application and System Modeling(2010计算机应用与系统建模国际会议 ICCASM 2010)

会议地点: 太原

会议语种:英文

页码: 55-59

在线出版日期: 2010-10-22（万方平台首次上网日期，不代表论文的发表时间）