Investigation of Osteoblast-like MC3T3-E1 Cells on a Collagen-like Protein and Poly (lactic-co-glycolic acid) Nanofibrous Composite Scaffold

摘要：

We present an effective emulsion eletrospinning method in obtaining collagen-like protein (denoted as Fol-8Col) and poly(lactic-co-glycolic acid) (PLGA) nanofibrous composite scaffolds. The reservation of Fol-8Cols chemical structure has been confirmed by FT-IR spectra on electrospun composite fibers. Importantly,compared to fibrous mat without Fol8Col,the osteoblastic behavior on the nanofibrous composite scaffolds was enhanced. The novelty of the process was that Fol-8Col in the scaffold had a positive modulation on early osteoblast adhesion and extension (within 24 hours) compared to neat PLGA. We concluded that this effective emulsion electrospinning is able to fabricate novel Fol8Col/PLGA nanofibrous composite scaffolds which is promising for bone tissue engineering application.

关键词： Nanofibrous Composite Electrospun composite fibers Collagen-like protein

作者: Yuan Li A.Teramoto K.Abe

作者单位: Department of Functional Polymer Science,Faculty of Textile Science and Technology,Shinshu University,Ueda,Nagano,Japan

会议类型: 国际会议

会议名称: The Second International Conference on Advanced Textile Materials & Manufacturing Technology(第二届先进纺织材料及加工技术国际会议)

会议地点: 杭州

会议语种:英文

页码: 59-62

在线出版日期: 2010-10-20（万方平台首次上网日期，不代表论文的发表时间）