A Mathematical Model of Myelodysplastic Syndromes:The Effect of Stem Cell Niches

摘要：

While myelodysplastic syndromes (MDS) are commonly observed nowadays, the underlying mechanisms remain unclear, not to mention mathematical models for MDS. In this work, by incorporating the concept of stem cell niches, we proposed a minimal mathematical model that can be used as a platform for studying the formation and treatment of MDS. Our model includes two main compartments: bone marrow and peripheral blood, in both compartment normal and abnormal cells exist. Simulation results show that 1) under normal condition, our model is robust to reproduce the hemopoiesis even with different perturbations; 2) by reducing stem cell niches, formation of MDS can be observed in our model; 3) treatments should be used to improve environment in bone marrow, rather than to kill the abnormal cells only.

关键词： myelodysplastic syndrome stem cell niche bone marrow peripheral blood

作者: Xiuwei Zhu Ling Xia Luyao Lu

作者单位: Key Lab of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China

会议类型: 国际会议

会议名称: International Conference on Life System Modeling and Simulation,and International Conference on Intelligent Computing for Sustainable Energy and Environment(2010生命系统建模与仿真国际会议暨m2010可持续能源与环境智能计算国际会议)

会议地点: 无锡

会议语种:英文

页码: 395-403

在线出版日期: 2010-09-17（万方平台首次上网日期，不代表论文的发表时间）