Computer Simulation on the Compaction of Chromatin Fiber Induced by Salt

摘要：

We present a computer simulation on the compaction of 30-nanometer chromatin fiber induced by salt. The nucleosome is represented as rigid oblate ellipsoids without consideration of DNA-histone wrapping conformation. It is found that equilibrium conformations of multi-nucleosome chains at physiological ionic concentrations are more or less random zig-zag structures. Moreover, the diameter, the linear mass density and the persistence length of fiber show a strong dependence on the ion strength. The computational results show us that decreasing the salt strength from 0.15M to 0.01M leads to an increase in the diameter and the linear mass density and a decrease in the persistence length.

关键词： chromatin fiber simulation salt compaction

作者: Chun-Cheng Zuo Yong-Wu Zhao Yong-Xia Zuo Feng Ji Hao Zheng

作者单位: Jilin University, College of Mechanical Science and Engineering 130025, China

会议类型: 国际会议

会议名称: International Conference on Life System Modeling and Simulation,and International Conference on Intelligent Computing for Sustainable Energy and Environment(2010生命系统建模与仿真国际会议暨m2010可持续能源与环境智能计算国际会议)

会议地点: 无锡

会议语种:英文

页码: 413-420

在线出版日期: 2010-09-17（万方平台首次上网日期，不代表论文的发表时间）