Modeling Conformation of Protein Loops by Bayesian Network
Modeling protein loops is important for understanding characteristics and functions for protein, but remains an unsolved problem of computational biology. By employing a general Bayesian network, this paper constructs a fully probabilistic continuous model of protein loops, refered to as LoopBN. Direct affection between amino acids and backbone torsion angles can be learned under the framework of LoopBN. The continuous torsion angle pair of the loops can be captured by bivariate von Mises distribution. Empirical tests are conducted to evaluate the performance of LoopBN based on 8 free modeling targets of CASP8. Experimental results show that LoopBN not only performs better than the state-ofthe-art modeling method on the quality of loop sample set, but also helps de novo prediction of protein structure by providing better sample set for loop refinement.
Modeling protein loop Bayesian network bivariate von Mises distribution
Peng Yang Qiang Lü Lingyun Yang Jinzhen Wu
School of Computer Science and Technology, Soochow University Jiangsu Provincial Key Lab for Informa School of Computer Science and Technology, Soochow University
国际会议
无锡
英文
430-438
2010-09-17（万方平台首次上网日期，不代表论文的发表时间）