PREPARATION AND EVALUATION OF ZANAMIVIR-LOADED SOLID LIPID NANOPARTICLES

摘要：

Zanamivir-loaded solid lipid nanoparticles (SLNs) were prepared by a double emulsion (W/O/W) solvent evaporation method, and the physicochemical properties of SLNs were evaluated. The SLNs prepared by optimal formulation had a spherical shape with a size of 183.9 nm, zeta potential of -53 mV, entrapment efficiency of 36.1％ and loading efficiency of 0.32％. Zanamivir partially existed in the amorphous state in the freeze-dried nanoparticles, and carriers resulted in significant decrease in the intensity of the endothermic melting peak of the drug. In vitro release profiles were affected by the volume of the outer aqueous phase. The double (W/O/W) emulsion solvent evaporation method was effective for preparing zanamivir-loaded SLNs with relatively high entrapment efficiency.

关键词： zanamivir SLNs double emulsion physicochemical properties

作者: Qingri Cao Haining Wu Li Zhu Dan Wu Yunfeng Zhu Zhixin Zhu Jinghao Cui

作者单位: School of Pharmacy, Medical College of Soochow University, 199 Renai Road, Suzhou Industrial Park, Suzhou 215123, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 66-68

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）