A SMART POLYMER FOR DRUG DELIVERY SENSITIVE TO TUMOR XTRACELLULAR pH

摘要：

A polymer sensitive to the slight acidic pH of tumor tissues was synthesized by introducing N-Boc-histidine to the ends of PLGA-PEG-PLGA block copolymer (PLGA: poly(D,L-lactic acid-co-glycolic acid), PEG: poly(ethylene glycol)). The corresponding micelles exhibited different in vitro release rates of an anti-cancer drug doxorubicin (DOX) between pH 6.2 and pH 7.4. The released DOX was confirmed able to be uptaken into MDA-MB-435 solid tumor cells. Hence, the N-Boc-histidine capped PLGA-PEG-PLGA might be a promising material for tumor targeting by enhanced release at tumor sites.

关键词： block copolymers tumor targeting pH-sensitive micelles

作者: Guangtao Chang Lin Yu Jiandong Ding

作者单位: Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Department of Macromolecular Science, Laboratory of Advanced Materials, Fudan University, Shanghai 200433,China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 69-71

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）