EFFECT OF RESISTANT STARCH FILM PROPERTIES ON THE COLON-TARGETING RELEASE OF DRUG FROM COATED PELLETS

摘要：

Resistant starch (RS) films were designed to target a protein to the colon by exploiting the colonic microbiota fermentative capacity. The RS films were coated to pellets and their mechanical resistance to the shear forces and the hydrostatic pressure within the pellets were investigated after contact with the gastrointestinal tract (GIT). In vitro tests showed that desired colon-targeted drug release can easily be obtained through controlling the proper relationship between enzymatic resistance and mechanical properties of RS film.

关键词： resistant starch film colon targeting mechanical properties controlled release pellets

作者: Xiaoxi Li Peng Liu Ling Chen Long Yu

作者单位: Engineering Research Center of Starch & Protein Processing, Ministry of Education, South China Unive Engineering Research Center of Starch & Protein Processing, Ministry of Education, South China Unive

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 72-74

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）