RAPIDLY pH-RESPONSIVE DEGRADABLE POLYMERSOMES FOR TRIGGERED RELEASE OF HYDROPHILIC AND HYDROPHOBIC ANTICANCER DRUGS

摘要：

Rapidly pH-responsive biodegradable polymersomes were prepared from block copolymers composed of poly(ethylene glycol) (PEG) and an acid-labile polycarbonate, poly(2,4,6-trimethoxybenzylidene-pentaerythritol carbonate) (PTMBPEC). The obtained polymersomes had average sizes of 100~200 nm. These polymersomes though sufficiently stable at pH 7.4 were prone to fast hydrolysis at mildly acidic pH of 4.0 and 5.0. These polymersomes were able to simultaneously load paclitaxel (PTX, hydrophobic) and doxorubicin hydrochloride (DOX·HCl, hydrophilic). The in vitro release studies demonstrated that both PTX and DOX-HCl were released in a pH-dependent manner.

关键词： pH-sensitive biodegradable polymersomes drug delivery

作者: Wei Chen Fenghua Meng Ru Cheng Zhiyuan Zhong

作者单位: Biomedical Polymers Laboratory and Jiangsu Key Laboratory of Organic Chemistry, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 75-77

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）