SINGLE CHAIN VARIABLE FRAGMENT CD7 ANTIBODY CONJUGATED PLGA/HDAC INHIBITOR IMMUNO-NANOPARTICLES: DEVELOPING HUMAN T CELL-SPECIFIC NANO-TECHNOLOGY FOR DELIVERY OF THERAPEUTIC DRUGS TARGETING LATENT HIV

摘要：

Latent HIV can be activated through inhibition of histone deacetylase using HDAC inhibitors (HDACi). Pleiotropic effects of HDAC include reactivation of other latent viruses. To minimize such risks, we have developed a novel PLGA immuno-nanoparticle for delivering HDACi exclusively to human T cells, the major reservoirs for latent HIV, using a single chain fragment antibody targeting the CD7 molecule on T cells. The immuno-nanoparticle successfully activated latent HIV in the human T cell line ACH2 and could deliver cargo to primary human T cells. This approach opens avenues for the eradication of HIV when used with HAART through elimination of HIV reservoirs.

关键词： latency virus HIV HDAC inhibitor PLGA scFvCD7 immuno-nanoparticle

作者: Sunmi Choi Jangwook Lee Priti Kumar Kuen Yong Lee Sang-Kyung Lee

作者单位: Department of Bioengineering,Hanyang University, Hangdang dong, Seongdong gu, Seoul 133-791, Korea,I Department of Internal Medicine, Yale University, 333 Cedar Street, PO Box 208022, New Haven,CT 0652 Department of Bioengineering,Hanyang University, Hangdang dong, Seongdong gu, Seoul 133-791, Korea,I

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 78-80

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）