SYNTHESIS AND CONTROLLED RELEASE OF MITOMYCIN C FROM A CHITOSAN-BASED POLYMERIC PRODRUG

摘要：

A chitosan-based polymeric prodrug of mitomycin C was synthesized and the release of mitomycin C from the prodrug was measured. The results showed that the higher the degree of aldehyde formation in chitosan, the more mitomycin C was trapped by imine bond formation in the polymeric prodrug. The drug release was controlled by the number of aldehyde groups in chitosan and the mass ratios of periodate-oxidized chitosan to mitomycin C.

关键词： chitosan mitomycin C polymeric prodrug fibroblast controlled release

作者: Lihong Duan Qiongjuan Zheng Xiaoning Li Daping Quan Jian Ge

作者单位: Institute of Polymer Science, College of Chemistry and Chemical Engineering, Sun yat-sen University, Zhongshan Ophthalmic Center, Sun yat-sen University, Guangzhou 510060, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 99-101

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）