DRUG RELEASE FROM BIODEGRADABLE POLYESTERURETHANES WITH SHAPE-MEMORY EFFECT

摘要：

Biodegradable polyesterurethane (PU) networks with shape memory properties have been synthesized and used as controlled release matrix for the model drug dexamethasone (DEX) in phosphate buffered saline pH = 7.0 at 37°C. The drug release courses of DEX could be divided into three stages as a typical erosion-controlled release mechanism. The crosslinking density of PU networks affected both degradation of the polymer networks and drug release rate.

关键词： polyurethanes biodegradability release shape-memory dexamethasone

作者: Yakai Feng Shifeng Zhang Heyun Wang Haiyang Zhao Jian Lu Jintang Guo Marc Behl Andreas Lendlein

作者单位: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China,Tianjin Uni School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China Tianjin University-GKSS Research Centre, Joint Laboratory for Biomaterials and Regenerative Medicine

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 102-104

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）