BIODEGRADABLE POLYESTERURETHANES WITH SHAPE-MEMORY PROPERTIES FOR DEXAMETHASONE AND ASPIRIN CONTROLLED RELEASE

摘要：

Biodegradable polyesterurethane (PU) networks with shape memory properties have been synthesized and used as controlled release matrix for dexamethasone (DEX) and aspirin (ASP) in phosphate buffered saline pH = 7.0 at 37 °C. The drug release courses of both model drugs could be divided into three stages as a typical erosion-controlled release mechanism. The crosslinking density affected both degradation of polymer networks and drug release rate. ASP accelerated the degradation process of PU owing to the acidic nature of ASP, which resulted in higher release rate of ASP than DEX.

关键词： polyurethanes biodegradability release shape-memory dexamethasone aspirin

作者: Yakai Feng Shifeng Zhang Heyun Wang Haiyang Zhao Jian Lu Jintang Guo Marc Behl Andreas Lendlein

作者单位: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China,Tianjin Uni School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China Tianjin University-GKSS Research Centre, Joint Laboratory for Biomaterials and Regenerative Medicine

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 105-108

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）