CROSSLINKED BIOMIMETIC RANDOM COPOLYMER MICELLES AS POTENTIAL ANTI-CANCER DRUG DELIVERY VEHICLE

摘要：

Amphiphilic random copolymers based on 2-(methacryloxyethyl) phosphorylcholine, stearyl methacrylate and trimethoxysilylpropyl methacrylate were synthesized using monomer-starved free radical polymerization method. The formation of micelles with cell outer membrane mimetic structure in aqueous solution was confirmed by fluorescence probe technique and scanning electron microscopy (SEM). Micellar stability against dilution and adjustable permeability were obtained by covalently crosslinking of the trimethoxysilyl groups in the micelle. The anti-cancer drug adriamycin (ADR) was incorporated into the micelles by oil-in-water method. The entrapped drug presents a sustained and remarkably slower release behavior without obvious burst effect.

关键词： polymeric micelle crosslinking membrane mimetic structure phosphorylcholine controlled release

作者: Jing Zhang Ming Gong Shan Yang Yong-kuan Gong

作者单位: Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education,Northwest University, Xian 710069, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 109-111

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）