STUDIES ON pH-SENSITIVE MICELLAR STRUCTURES FOR SUSTAINED DRUG DELIVERY:EXPERIMENTS AND COMPUTER SIMULATIONS

摘要：

Computer simulations were performed to study the microstructures of doxorubicin (DOX) loaded micelles self-assembled from cholesterol conjugated His10Arg10 at different pH conditions. DOX molecules can be efficiently encapsulated in the core of micelles. With the decrease of pH from pH>6.0 to pH<6.0, the structure of the micelles changes from dense to more swollen. This structural transformation can facilitate the release of DOX from the core of micelles. All the simulation results are consistent with the experimental results qualitatively.

关键词： drug delivery micelle ph-sensitive amphiphilic dissipative particle dynamics

作者: Xin Dong Guo Li Juan Zhang Zhi Min Wu Yu Qian

作者单位: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 115-117

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）