PEGYLATED LIPOSOMES MODIFIED WITH LHRH ANALOGS FOR TUMOR TARGETING

摘要：

A sterically stabilized, mitoxantrone-loaded liposome, tailored to target luteinizing hormone-releasing hormone (LHRH) receptor over-expressing cells, was developed to promote the efficiency of intracellular delivery of mitoxantrone through receptor-mediated endocytosis. Liposomes were prepared by lipid film hydration and an ultrasound dispersion process. The thiolated gonadorelin, with affinity for LHRH receptor was chemically coupled to N-(3-maleimide-l-oxopropyl) aminopropyl polyethylene glycol-carbamyl distearoy-1-phosphatidyl-ethanolamine (Mal-PEG-DSPE) via a thioether bond and subsequently inserted into PEGylated liposomes using the post insertion technique. The liposomes were characterized in terms of their size, ligand density, drug loading, and leakage properties. The targeting nature and anti-tumor effects of the liposomes were evaluated in vitro using cultured MCF-7 breast cancer cells.

关键词： mitoxantrone(MTX) liposome luteinizing hormone-releasing hormone(LHRH) tumor targeting

作者: Yingna He Linhua Zhang Cunxian Song

作者单位: Institute of Biomedical Engineering, Peking Union Medical College and Chinese Academy of Medical Sciences, Tianjin, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 121-123

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）