PHOTOSENSITIZER-LOADED DENDRIMER-MODIFIED MULTI-WALLED CARBON NANOTUBES FOR PHOTODYNAMIC THERAPY

摘要：

Polyamidoamine dendrimer modified multi-walled carbon nanotubes (dMNTs) have been explored as new vehicles to deliver the photosensitizer 5-aminolevulinic acid (5-ALA) to tumor MGC-803 cells. Intense fluorescence of protoporphyrin IX (PpIX) was monitored in the cytoplasm of MGC-803 cells. The nanocarriers possessed good biocompatibility and can significantly increase the accumulation of photosensitizer in tumor cells, leading to remarkable photodynamic anti-tumor effects.

关键词： carbon nanotubes dendrimer photosensitizer 5-aminolevulinic acid protoporphyrin IX

作者: Peng Huang Jing Lin Dapeng Yang Chuilei Zhang Zhiming Li Daxiang Cui

作者单位: Department of Bio-Nano-Science and Engineering, National Key Laboratory of Nano/Micro Fabrication Technology, Key Laboratory for Thin Film and Microfabrication of Ministry of Education,Institute of Micro-Nano Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 127-129

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）