PREPARATION AND CHARACTERIZATION OF ASPIRIN/CHITOSAN NANOPARTICLES BY NUCLEATION AND IONIC CROSSLINKING IN MICRO EMULSIONS

摘要：

Chitosan nanoparticles loaded with aspirin (aspirin/chitosan) were prepared by a process of nucleation and ionic crosslinking in micro emulsions for medical and pharmaceutical applications. The nanoparticles were characterized by Fourier transform infrared spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, dynamic laser light scattering and X-ray powder diffraction, respectively. In vitro release profiles under different conditions were determined using an UV/Vis spectrophotometer and the results showed that the nanoparticles displayed an excellent drug-controlled release behavior.

关键词： chitosan nanoparticle nucleation in micro emulsion controlled drug release conformation

作者: Shuping Jin Lei Feng Xinghai Yu

作者单位: Key Laboratory of Resources and Environmental Chemistry of West China, Department of Chemistry,Hexi University, Zhangye 734000, China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 139-141

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）