EXPERIMENTAL STUDY ON BIODEGRADABLE POLYMER-PACLITEXAL CONJUGATE MICELLES FOR CHEMOTHERAPY OF C6 GLIOMA

摘要：

An intracranial C6 glioma model was constructed using Wistar rats. Paclitaxel (PTX) was conjugated to biodegradable diblock copolymer PEG-PLA to form water-soluble PEG-PLA-PTX micelles. The tumor-bearing rats were treated with blank PEG-PLA micelles, commercial Taxol, and PEG-PLA-PTX micelles, respectively, via tail vein injection. With the same equivalent PTX dose, the PEG-PLA-PTX micelles displayed enhanced inhibition ability to tumor growth as shown by the body weight change, survival time and tumor image size. This improved therapeutic effect was ascribed to the EPR effect of the PEG-PLA-PTX micelles. Fluorescent imaging of the brain slice further confirmed that the PEG-PLA-PTX micelles can pass the BBB and remain in the brain even 5 days post drug administration.

关键词： C6 glioma Wistar rats paclitaxel Taxol pro-drug EPR effect BBB

作者: Zhanfeng Wang Xiuli Hu Jun Yue Xiabin Jing

作者单位: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chin Affiliate Hospital of Beihua University, Jilin 132011, China State Key Laboratory of Polymer Physics State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chin State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chin

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 142-144

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）