TAILORING THE PLATMC CHAIN MICROSTRUCTURE FOR STABLE CYCLOSPORINE A RELEASE

摘要：

Tailoring the chain microstructure of poly(lactide-co-trimethylenecarbonate) (PLATMC) lead up to obtain copolymer with 74:26 comonomer molar ratio and specific chain microstructure (randomization coefficient R=0.7). The copolymer was used to form matrices containing cyclosporine A (CyA). Regular degradation was determined, which caused also uniform CyA release profile. The PLATMC 74:26 (R=0.7) matrices with CyA may have high potential in development of drug eluting stents and other surgical devices with shape memory properties; anti-restenotic stent coating or implants used after organ transplantation.

关键词： PLATMC controlled drug release cyclosporine A microstructure shape memory

作者: Janusz Kasperczyk Katarzyna Jelonek Katarzyna Gebarowska Piotr Dobrzynski Anna Smola

作者单位: Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze 41-819, Poland,Department Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze 41-819, Poland

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 145-147

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）