ANTI-CANCER EFFECTS OF DOCETAXEL LOADED THERMO-REVERSIBLE HYDROGELS IN A TUMOR XENOGRAFT MICE MODEL

摘要：

Thermo-reversible hydrogels consisting of low molecular weight methycellulose (LMwMC), pluronic F127 polymer and ammonium sulfate (AS) were optimized for controlled release of the hydrophobic drug, docetaxel (DTX). DTX loaded themo-reversible hydrogels showed sustained release of DTX over 25 days with no significant burst release. Compared to free DTX, DTX loaded hydrogel significantly reduced tumor growth and increased the survival rate of B16-F10 melanoma cancer cell bearing mice. Injectable and thermo-reversible hydrogels can be widely applied as efficient carriers for hydrophobic anti-cancer drugs.

关键词： docetaxel anti-cancer thermo-reversible hydrogel biocompatible natural polymer

作者: Jang-Kyoung Kim Young-Wook Won Kwang Suk Lim Eun Jeong Park Yong-Hee Kim

作者单位: Department of Bioengineering, Hanyang University,17, Haengdang-dong, Seongdong-gu, Seoul 133-791, Ko Department of Bioengineering, Hanyang University,17, Haengdang-dong, Seongdong-gu, Seoul 133-791, Ko

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 148-150

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）