FORMATION OF CONCENTRIC MULTI-LAYER CHITOSAN HYDROGEL LOADED WITH ISONIAZID

摘要：

A novel chitosan hydrogel with concentric multi-layers is constructed by a reaction-diffusion system, and isoniazid is used to investigate its application in drug upload and release. The results show that concentric multi-layers can be obtained when the flocculation of the OH-concentration is realized by periodically immersing in water bath. The structure of concentric multi-layer chitosan favors to absorb the drug solution and the maximum loading efficiency of isoniazid is 14.60±1.59％. The isoniazid release kinetics obey the diffusion-erosion model.

关键词： chitosan hydrogel concentric multi-layers isoniazid drug release

作者: Baoqiang Li Yongsheng Gao Yujie Feng Bing Ma Renxian Zhu Yu Zhou

作者单位: Institute for Advanced Ceramics,Harbin Institute of Technology, P.O.Box 433, Harbin 150001, China,St Institute for Advanced Ceramics,Harbin Institute of Technology, P.O.Box 433, Harbin 150001, China State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology, P.O.Box

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 151-153

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）