CHITOSAN HYDROGELS WITH 3D LIESEGANG RING STRUCTURE FOR RIFAMPICIN RELEASE

摘要：

Polymer hydrogels with patterned structures are desirable for tissue engineering scaffolds or drug delivery carriers. Based on alternate soaking reaction diffusion, chitosan hydrogels with a 3D Liesegang ring (LR) structure were constructed without external crosslinking reagents. The alternate soaking process regulated the periodic fluctuation of the OH-concentration. The features of the LR structure were consistent with the time law and spacing law of LR phenomena. Release behavior of rifampicin was dominated by drug diffusion kinetics and chitosan relaxation.

关键词： chitosan hydrogel liesegang ring concentric layer

作者: Baoqiang Li Yongsheng Gao Xin Li Yujie Feng Yu Zhou

作者单位: Institute for Advanced Ceramics,Harbin Institute of Technology, P.O.Box 433, Harbin 150001, China,St Institute for Advanced Ceramics,Harbin Institute of Technology, P.O.Box 433, Harbin 150001, China State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology, P.O.Box

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 154-156

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）