FUNCTIONALIZED DEXTRAN-COATED LIPOSOMES FOR DOXORUBICIN LOADING

摘要：

Functionalized dextran coated-liposomes (FD-LIPs) consisting of unsaturated alkyl hydrophobic moieties and targeting parts were prepared. The experimental results showed that the existence of dextran on the nanoparticles obviously decreases the protein adsorption, and provides for further attachment of targeting ligands. FD-LIPs are of narrow distribution with 110 nm in diameter. In addition, FD-LIPs showed a high doxorubicin loading efficiency of 98％ and a sustained release of doxorubicin in comparison with the uncoated drug-loaded liposomes in vitro.

关键词： liposome dextran drug-loading

作者: Shunhua Ning Qiyu Huang Juan Li Yi Zhang You-Nian Liu

作者单位: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083,China

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 157-159

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）