A NOVEL ORAL COLON-TARGETING DRUG DELIVERY SYSTEM BASED ON RESISTANT STARCH ACETATE

摘要：

Novel oral colon-targeting film-coated pellets based on resistant starch acetate (RSA) film were prepared and the effect of plasticizer content, film coating thickness, drug load and drug molecular weight on drug release was investigated. Desired colon-targeting and drug release properties can easily be obtained by adjusting the coating thickness as well as the plasticizer content of the RSA film. This suggested that RSA film coated-pellet is an excellent and potential oral colon targeting drug delivery system.

关键词： colon-targeting resistant starch acetate film-coated pellets in vitro drug release

作者: Ling Chen Huayin Pu Xiaoxi Li Long Yu

作者单位: Engineering Research Center of Starch & Protein Processing, Ministry of Education, South China Unive Engineering Research Center of Starch & Protein Processing, Ministry of Education, South China Unive

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 160-162

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）