SUPRAMOLECULAR POLYMER MICELLES SELF-ASSEMBLED FROM α-CYCLODEXTRIN AND PLLA-PCL BASED COPOLYMERS

摘要：

We report here a new supramolecular polymer micelle (SMPM) constructed from α-CD derivatives (MAh-α-CD) and PCL/PLLA based copolymer guests with different structure regularity via host-guest and hydrophobic interactions. SMPMs are composed of hydrophilic MAh-α-CD threaded polymer chains and hydrophobic unthreaded chains. Structure regularity was found to play an important role in SMPMs formation, reflecting by the random structure of copolymer being more favorable for SMPMs formation. Potential application of SMPMs in drug delivery was further evaluated.

关键词： Supramolecular polymer micelle poly(ε-caprolactone) poly(lactic acid) α-cyclodextrin

作者: Haiqing Dong Yongyong Li Huiyun Wen Donglu Shi

作者单位: The Institute for Advanced Materials and Nano Biomedicine (iNANO), Tongji University, Shanghai 20009 The Institute for Advanced Materials and Nano Biomedicine (iNANO), Tongji University, Shanghai 20009

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 163-165

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）