REVERSIBLY CROSSLINKED POLY(VINYL ALCOHOL) NANOPARTICLES FOR TRIGGERED RELEASE OF DOXORUBICIN

摘要：

A novel class of reversibly crosslinked nanoparticles based on poly(vinyl alcohol)-lipoic acid (PVA-LA) conjugates was developed for triggered intracellular release of doxorubicin (DOX). The crosslinked PVA-LA nanoparticles showed excellent stability with less than 20％ drug release in 12 h. However, under an intracellular-mimicking reductive condition, rapid and quantitative release of DOX was observed. The intracellular release studies showed that DOX-loaded crosslinked PVA-LA nanoparticles efficiently delivered and released DOX into HeLa cells. DOX loaded crosslinked nanoparticles revealed a similar drug efficacy to the non-crosslinked counterparts.

关键词： biodegradable reduction-sensitive PVA nanoparticles crosslink drug delivery

作者: Yuling Li Rongran Wei Shunjun Ji Fenghua Meng Zhiyuan Zhong

作者单位: Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province,College Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province,College

会议类型: 国际会议

会议名称: The First Symposium on Innovative Polymers for Controlled Delivery(新型高分子材料与控制释放国际会议 SIPCD 2010)

会议地点: 苏州

会议语种:英文

页码: 166-168

在线出版日期: 2010-09-14（万方平台首次上网日期，不代表论文的发表时间）